The Pope criticized Trump’s expected initiative for the substantial expulsion of undocumented immigrants as one that does not effectively address the underlying issues of migration. He reiterated his long-standing stance on the treatment of migrants, recalling his remarks from a public audience last year, where he categorized the systemic driving away of migrants as "a grave sin".

Francis had previously alluded to Trump's wall on the Mexican border, asserting that a leader who prioritizes building walls over bridges cannot truly embody Christian values. The two leaders had met in 2017 to discuss various issues, but Francis refrained from endorsing any political candidate ahead of the 2024 elections, advising voters to follow their conscience and choose "the lesser evil."

During the interview, the Pope also referenced the plight of migrants in Europe, pointing out the "cruelty" they face and affirming both the right to stay and the right to migrate. He emphasized that many southern European nations, struggling with declining birth rates, could benefit from a well-planned migration policy.

Additionally, when discussing ongoing global conflicts in Ukraine and the Middle East, Francis expressed bewilderment at the complexities involved in achieving peace, reflecting, "it's as if there was an international drive towards self-destruction." Since taking office in 2013, the 88-year-old pontiff has consistently advocated for compassionate treatment of migrants, focusing on their human rights.