US Secretary of State Marco Rubio is meeting Israeli Prime Minister Benjamin Netanyahu in Jerusalem, with the aftermath of Israel's strike in Qatar last week expected to be high on the agenda.
The strike, which targeted senior Hamas leaders on the close US ally's territory, drew international outrage and was criticized by President Donald Trump.
Rubio earlier told reporters: Obviously we're not happy about it. The president was not happy about it. Now we need to move forward and figure out what comes next.
The meeting comes as Arab leaders hold a summit in a show of support for Qatar. Its prime minister urged the international community to stop applying double standards and to punish Israel.
The Gulf state hosts a major US airbase and has played a key role in brokering diplomatic efforts to end the war in Gaza, serving as a mediator of indirect negotiations between Hamas and Israel.
On Sunday, Netanyahu told reporters that the US-Israel relationship was as durable as the stones in the Western Wall while he and Rubio made a short visit to the holy site in Jerusalem's Old City.
Also expected to be under discussion between the pair are Israeli military plans to seize Gaza City and Israel's continued expansion of settlements in the occupied West Bank.
The meeting comes ahead of a UN General Assembly meeting next week, at which some leading US allies - including the UK, France, Canada, Australia and Belgium - are expected to recognise the State of Palestine.